Week 1: Open Book Quiz Answers and Rationales

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Question 2:Which antibiotic does the course textbook recommend for treating a UTI in breastfeeding women?

• Answer: Short-term Fluoroquinolones
• Rationale: This information can be found in the Summary of Key Prescribing Considerations in the chapter that covers this drug class.

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Question 3:Which patients being treated with a penicillin are at high risk for toxicity? (Select all that apply)

• Answer:
  • Renal impaired
  • Acutely ill
  • Very young
  • Very old
• Rationale: Renal impairment causes the half-life to increase dramatically and may necessitate a reduction in dosage. In patients at high risk for toxicity (those with renal impairment, the acutely ill, the very young, and older adults), kidney function should be monitored. (p. 665)

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Question 4:Which antibiotic class is most likely to be given to someone with otitis media if there are no contraindications?

• Answer: Penicillin
• Rationale: After 3 days of observation, start 10 days of amoxicillin or amoxicillin/clavulanate. Information found in the course module.

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Question 5:Locate the Prescribers' Digital Reference website (pdr.net) to answer this question. A patient is prescribed Amoxicillin for an infection. They have a creatinine clearance of 24 mL/min. What dose of amoxicillin should they be prescribed?

• Answer: 250-500 mg PO every 12 hours
• Rationale: The following dosing recommendations pertain to adults. No specific dosage adjustments for pediatric patients with renal impairment are available at this time; however, dosage intervals should be adjusted. CrCl > 30 mL/min: no dosage adjustment needed. CrCl 10—30 mL/min: 250—500 mg PO every 12 hours, depending on the severity of the infection. Do not use the 875 mg-tablet strength or the extended-release tablet for dosing. CrCl < 10 mL/min: 250—500 mg PO every 24 hours, depending on the severity of the infection. Do not use the 875 mg-tablet strength or the extended-release tablet for dosing. PDR Amoxicillin

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Question 6:Which medication requires patient education to avoid prolonged exposure to sunlight?

• Answer: Tetracyclines
• Rationale: This information can be found in the Summary of Key Prescribing Considerations in the chapter that covers this drug class.

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Question 7:Using your textbook, match the antibiotic class to the patient care concern for pregnant persons. Use each option only once by selecting the option that is most true.

• Answer: Cephalosporins - All appear to be safe for use in pregnancy.
• Rationale: Although there are no well-controlled studies in pregnant women, evidence suggests there is no second or third trimester fetal risk.